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Inherited hypercoagulable states

A K Rao1, S Sheth, R Kaplan

  • 1Division of Hematology and Thromboembolic Diseases, Temple University School of Medicine, Philadelphia, PA 19140, USA.

Vascular Medicine (London, England)
|May 12, 1998
PubMed
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Inherited hypercoagulable states, like protein deficiencies and factor V Leiden, increase the risk of venous thromboembolism (VTE). Understanding these thrombophilias is crucial for diagnosis and management.

Area of Science:

  • Hematology
  • Genetics
  • Internal Medicine

Background:

  • Hypercoagulable states predispose individuals to thromboembolic events.
  • Most inherited abnormalities are linked to venous thromboembolism (VTE), not arterial thrombosis.

Purpose of the Study:

  • To review the risks of VTE associated with inherited risk factors.
  • To present guidelines for the diagnosis and management of inherited thrombophilias.

Main Methods:

  • Review of scientific literature on inherited hypercoagulable states.
  • Discussion of established and emerging inherited thrombophilias.
  • Analysis of VTE risk factors in relation to inherited conditions.

Main Results:

  • Key inherited hypercoagulable states include deficiencies in antithrombin, protein C, protein S, and factor V Leiden resistance.

Related Experiment Videos

  • Other inherited thrombophilias involve fibrinolytic system proteins, dysfibrinogenemias, and prothrombin gene variations.
  • Hyperhomocysteinemia is a significant risk factor for recurrent VTE.
  • Approximately 50% of VTE episodes in patients with inherited thrombophilias occur alongside triggers like surgery, pregnancy, or immobilization.

    • Conclusions:

    • Inherited thrombophilias represent significant risks for VTE.
    • Guidelines for diagnosis and management are essential for affected individuals.
    • Further research into genetic predispositions for thrombosis is warranted.