Related Experiment Videos
Pemphigus vegetans involving the esophagus
1Department of Dermatology, Yamaguchi University School of Medicine, Ube, Japan.
The Journal of Dermatology
|May 12, 1998
Summary
Pemphigus vegetans can cause severe esophageal pain (odynophagia) due to white, plaque-like lesions. Biopsies reveal characteristic epidermal changes and inflammation, confirming esophageal involvement.
Area of Science:
- Dermatology
- Gastroenterology
- Pathology
Background:
- Pemphigus vegetans is a rare autoimmune blistering disease.
- Esophageal involvement can lead to significant odynophagia and dysphagia.
Observation:
- A 44-year-old male patient presented with severe odynophagia.
- Endoscopic examination revealed white plaque-like lesions with erythematous bases on the esophageal mucosa.
Findings:
- Biopsy confirmed mucosal epithelial changes consistent with pemphigus vegetans.
- Histopathology showed rounded epidermal cells with large nuclei and significant inflammatory infiltrate, including eosinophils.
Implications:
- This case highlights the importance of considering esophageal involvement in patients with pemphigus vegetans presenting with odynophagia.
- Early diagnosis and management of esophageal lesions can improve patient outcomes and quality of life.