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Cerebral cortex does not modulate "regulated" decrease in core temperature during hypoxemia in rats

E L Rollins1, J E Fewell

  • 1Department of Physiology and Biophysics, University of Calgary, Health Sciences Centre, Alberta, Canada.

The American Journal of Physiology
|May 12, 1998
PubMed
Summary
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The cerebral cortex does not modulate the regulated decrease in core body temperature during acute hypoxemia (low oxygen). This study found that functional decortication did not alter hypoxemia-induced hypothermia in adult rats.

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • Acute hypoxemia (low oxygen) causes a regulated decrease in core body temperature in many species, including humans.
  • The exact mechanism behind this hypothermia is not fully understood.
  • The cerebral cortex is involved in autonomic regulation, including thermoregulation.

Purpose of the Study:

  • To investigate the role of the cerebral cortex in modulating the regulated decrease in core body temperature during acute hypoxemia.
  • To test the hypothesis that the cerebral cortex influences hypothermia induced by low oxygen levels.

Main Methods:

  • Experiments were conducted on adult Sprague-Dawley rats.
  • Core body temperature responses to acute hypoxemia were measured before and after inducing cortical spreading depression (functional decortication) using potassium chloride application.

Related Experiment Videos

  • Baseline core temperature was monitored to assess the effect of functional decortication.

    • Main Results:

    • Functional decortication had no impact on baseline core body temperature.
    • Core body temperature decreased similarly during acute hypoxemia in rats with an intact cerebral cortex and those with functional decortication.
    • The data did not support the hypothesis that the cerebral cortex plays a role in modulating hypothermia during acute hypoxemia.

    Conclusions:

    • The cerebral cortex does not appear to modulate the regulated decrease in core body temperature observed during acute hypoxemia in adult rats.
    • Further research is needed to elucidate the neural pathways involved in hypoxemia-induced hypothermia.