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Related Experiment Video

Updated: Jul 21, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

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Published on: August 18, 2015

Thrombotic storm: when thrombosis begets thrombosis

¹Department of Medicine, University of Florida, and Department of Veterans Affairs Medical Center, Gainesville 32608-1197, USA.

The American Journal of Medicine

|May 12, 1998

Summary

Patients experiencing a thrombotic storm have an underlying hypercoagulable disorder and a trigger, leading to rapid new clots. Prompt anticoagulant therapy can interrupt this cycle, improving prognosis.

Area of Science:

Hematology
Vascular Medicine
Thrombosis Research

Background:

Hypercoagulable states predispose individuals to thrombosis.
Inadequate anticoagulation can lead to progressive and potentially fatal thrombotic events.
The concept of 'thrombotic storm' describes a severe manifestation of hypercoagulability.

Observation:

Six cases illustrate the 'thrombotic storm' syndrome.
Key features include an underlying hypercoagulable disorder and a thrombotic provocation.
Rapid development of new thromboses is characteristic, often responding to prompt thrombolytic or anticoagulant therapy.

Findings:

The syndrome is hypothesized to be caused by continuous coagulation activation from fresh thrombosis.
This continuous activation explains the effectiveness of anticoagulant therapy in managing the condition.

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While not a new disorder, thrombotic storm represents an extreme presentation of hypercoagulability.

Implications:

Early recognition and intervention are crucial for interrupting the thrombotic cycle.
Prompt treatment with anticoagulants or thrombolytics can significantly improve patient outcomes.
Understanding thrombotic storm aids in managing severe hypercoagulable states and preventing mortality.