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Related Experiment Videos

Thrombotic storm: when thrombosis begets thrombosis

C S Kitchens1

  • 1Department of Medicine, University of Florida, and Department of Veterans Affairs Medical Center, Gainesville 32608-1197, USA.

The American Journal of Medicine
|May 12, 1998
PubMed
Summary

Patients experiencing a thrombotic storm have an underlying hypercoagulable disorder and a trigger, leading to rapid new clots. Prompt anticoagulant therapy can interrupt this cycle, improving prognosis.

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Area of Science:

  • Hematology
  • Vascular Medicine
  • Thrombosis Research

Background:

  • Hypercoagulable states predispose individuals to thrombosis.
  • Inadequate anticoagulation can lead to progressive and potentially fatal thrombotic events.
  • The concept of 'thrombotic storm' describes a severe manifestation of hypercoagulability.

Observation:

  • Six cases illustrate the 'thrombotic storm' syndrome.
  • Key features include an underlying hypercoagulable disorder and a thrombotic provocation.
  • Rapid development of new thromboses is characteristic, often responding to prompt thrombolytic or anticoagulant therapy.

Findings:

  • The syndrome is hypothesized to be caused by continuous coagulation activation from fresh thrombosis.
  • This continuous activation explains the effectiveness of anticoagulant therapy in managing the condition.
  • While not a new disorder, thrombotic storm represents an extreme presentation of hypercoagulability.

Implications:

  • Early recognition and intervention are crucial for interrupting the thrombotic cycle.
  • Prompt treatment with anticoagulants or thrombolytics can significantly improve patient outcomes.
  • Understanding thrombotic storm aids in managing severe hypercoagulable states and preventing mortality.

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