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Accelerated right colonic emptying after simulated upper gut hemorrhage
1Universitätsklinik für Innere Medizin IV, Abteilung für Gastroenterologie und Hepatologie, Vienna, Austria.
The American Journal of Gastroenterology
|May 12, 1998
Summary
Simulated upper gastrointestinal bleeding accelerates proximal colonic transit in healthy volunteers. Small intestinal and ileocecal transit times remained unaffected by the induced bleeding.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Upper gastrointestinal hemorrhage is known to delay gastric emptying.
- The impact on downstream gastrointestinal transit remains less understood.
Purpose of the Study:
- To investigate the effect of simulated upper gastrointestinal bleeding on small intestinal, ileocecal, and proximal colonic transit.
- To differentiate the effects on various segments of the gastrointestinal tract.
Main Methods:
- Healthy volunteers underwent duodenal infusion of either heparinized autologous blood or egg white (control).
- 99mTc-DTPA radiolabel was added to track transit.
- Gamma-camera imaging quantified radiolabel arrival and colonic counts over 4 hours.
Main Results:
- No significant differences in small intestinal or ileocecal transit were observed between blood and egg white groups.
- Ascending colonic emptying was significantly faster following blood infusion compared to egg white.
- Four hours post-infusion, 30% of counts were in the transverse colon after blood, versus 0% after egg white (p < 0.001).
Conclusions:
- Simulated upper gastrointestinal bleeding accelerates proximal colonic transit.
- Small intestinal transit and overall colonic filling are not altered by simulated upper gastrointestinal bleeding.