Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic changes associated with primary Merkel cell carcinoma

A O Vortmeyer1, M J Merino, R Böni

  • 1Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

American Journal of Clinical Pathology
|May 12, 1998
PubMed
Summary

Merkel cell carcinoma (MCC) shares genetic changes on chromosome 1p with neural crest tumors. This suggests a common origin for MCC and other neuroendocrine cancers, aiding in understanding cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seizure freedom from recurrent insular low-grade glioma following laser interstitial thermal therapy.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2020
Same author

Correlation among olfactory function, motors' symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson's disease.

Journal of neurology·2018
Same author

Brainstem melanomas presenting as a cavernous malformation.

Neuro-Chirurgie·2014
Same author

Perception of the Ebbinghaus illusion in four-day-old domestic chicks (Gallus gallus).

Animal cognition·2013
Same author

AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells.

Leukemia·2012
Same author

[Clinical value of antibodies to lysobisphosphatidic acid in patients with primary antiphospholipid syndrome].

Reumatismo·2010

Area of Science:

  • Oncology
  • Genetics
  • Dermatology

Background:

  • Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with a neuroendocrine phenotype.
  • Its precise histogenetic origin remains unclear.
  • Previous studies suggest chromosome 1 alterations in MCC and other neuroendocrine tumors.

Purpose of the Study:

  • To investigate loss of heterozygosity (LOH) on the distal portion of chromosome 1p in primary Merkel cell carcinoma.
  • To compare genetic alterations in MCC with those found in other neuroendocrine tumors of neural crest origin.

Main Methods:

  • Analysis of LOH at polymorphic markers D1S160, D1S243, D1S468, D1S1646, and D1S1598.
  • Utilized paraffin-embedded primary MCC tissue samples (n=10) after microdissection.

Related Experiment Videos

Main Results:

  • Seven out of 10 primary MCC samples exhibited a shared deletion on the distal 1p35-36 region.
  • No involvement of chromosome 1 proximal to 1p35 was observed.
  • The observed genetic changes in MCC mirror those found in malignant melanoma, pheochromocytoma, and neuroblastoma.

Conclusions:

  • Merkel cell carcinoma exhibits genetic alterations consistent with tumors derived from neural crest cells.
  • These findings support the hypothesis that MCC shares pathogenetic mechanisms with other neuroendocrine neoplasms of neural crest origin.
  • Understanding these shared mechanisms may offer new insights into MCC development and potential therapeutic targets.