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Soy protein isolate diet does not prevent increased cortical bone turnover in ovariectomized macaques
1Department of Comparative Medicine, Bowman Gray School of Medicine, Medical Center Boulevard, Wake Forest University, Winston-Salem, North Carolina 27157-1040, USA.
Calcified Tissue International
|June 20, 1998
Summary
Estradiol reduces bone formation in ovariectomized monkeys, irrespective of diet. Soy protein alone did not prevent increased bone turnover and may worsen it, unlike casein/lactalbumin diets.
Area of Science:
- Endocrinology
- Bone Biology
- Nutritional Science
Background:
- Ovariectomy in non-human primates leads to increased bone turnover.
- Dietary protein sources may influence bone metabolism.
- Estrogen deficiency is a key factor in postmenopausal bone loss.
Purpose of the Study:
- To investigate the effects of 17beta-estradiol on bone formation rates in ovariectomized monkeys.
- To compare the impact of soy protein versus casein/lactalbumin diets on bone turnover.
- To determine if dietary protein source modulates the effects of 17beta-estradiol on bone.
Main Methods:
- Forty-one ovariectomized cynomolgus monkeys were used.
- Animals were fed diets with or without 17beta-estradiol, using either soy protein or casein/lactalbumin.
- Histomorphometry was performed on femur cortical bone after 7 months.
Main Results:
- 17beta-estradiol significantly suppressed ovariectomy-induced increases in bone formation rates.
- This suppression occurred regardless of the dietary protein source (soy or casein/lactalbumin).
- Soy protein alone, without 17beta-estradiol, increased bone turnover on the endosteal surface compared to casein/lactalbumin.
Conclusions:
- 17beta-estradiol is effective in reducing bone formation rates post-ovariectomy.
- Dietary soy protein alone does not mitigate increased bone turnover and may exacerbate it.
- The source of dietary protein may influence bone turnover dynamics, independent of estrogen status.