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[Antiphospholipid syndrome in obstetrics]

R Corosu1, B Roma, M Cocola

  • 1I Clinica Ostetrica e Ginecologica, Università degli Studi di Roma La Sapienza, Roma.

Minerva Ginecologica
|May 13, 1998
PubMed
Summary

Antiphospholipid syndrome in pregnancy is linked to fetal loss and hypertension. Treatment strategies, including aspirin and prednisone, appear to improve fetal outcomes, warranting further investigation for these high-risk pregnancies.

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Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Reproductive Medicine

Context:

  • Antiphospholipid antibody syndrome (APS) is characterized by thrombotic events, recurrent pregnancy loss, and thrombocytopenia.
  • Key autoantibodies include lupus anticoagulant (LAC) and anticardiolipin antibody (ACA).
  • This study focuses on APS in pregnant patients with a history of fetal wastage or maternal hypertension, excluding those with other autoimmune diseases.

Purpose:

  • To determine the frequency of antiphospholipid syndrome in pregnant patients experiencing fetal wastage or maternal hypertension.
  • To evaluate the association between autoantibodies and adverse pregnancy outcomes.
  • To assess the effectiveness of treatment strategies on fetal outcomes in APS.

Summary:

  • A cohort of 83 pregnant patients was studied for autoantibodies; 45 had a history of fetal wastage, and 38 had maternal hypertension.

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  • Autoantibody prevalence was 31.1% in the fetal wastage group and 21% in the hypertension group.
  • Treatment with aspirin and prednisone showed a favorable impact on fetal outcomes, reducing fetal loss in treated pregnancies.

    • Impact:

    • Treatment strategies for antiphospholipid syndrome in pregnancy can favorably alter fetal outcomes.
    • Early detection and management of APS are crucial for preventing recurrent pregnancy loss.
    • This research supports the need for continued investigation into therapeutic interventions for APS during pregnancy.