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[Effect of hormone replacement therapy on postmenopausal ocular function]
C Sorrentino1, P Affinito, F Mattace Raso
1Facoltà di Medicina e Chirurgia, Cattedra di Ostetricia e Ginecologia, Università degli Studi Federico II, Napoli.
Objective:
Determination of the effects of hormonal replacement therapy (HRT) on various ocular parameters and symptoms in postmenopausal women.
Design:
Prospective study.
Setting:
Department of Obstetrics and Gynecology, University "Federico II" of Naples.
Patients:
14 healthy women treated orally with equine conjugated estrogen in continuous (0,625 mg/daily) and acetate-medroxyprogesteron (10 mg/daily) from 17th to 28th day for three months.
Measures:
Ocular symptomatology, intraocular pressure (IOP), lacrimal secretion, reflected and basal and corneal thickness.
Results:
After 3 months of HRT the IOP was reduced of 10.8% (p < 0.005), the lacrimal secretion, reflected and basal, increased of 19% and 48%, respectively and the corneal thickness increased of 16.6%.
Conclusion:
The HRT has a positive effect on ocular physiology.