Related Experiment Videos
Venous thrombosis in a replanted finger with underlying factor V Leiden mutation
L Kenner1, F Schwarzl, H Moshammer
1Department of Neurosurgery, University School of Medicine, Graz, Austria.
British Journal of Plastic Surgery
|May 13, 1998
Summary
Activated protein C (APC) resistance, a cause of thrombophilia, is linked to Factor V Leiden mutation. This case highlights APC resistance and Factor V Leiden in venous thrombosis after finger replantation.
Area of Science:
- Hematology
- Vascular Surgery
- Genetics
Background:
- Activated protein C (APC) resistance is a known thrombophilia.
- Factor V Leiden mutation is the most common cause of APC resistance.
- APC resistance impacts coagulation factors Va and VIIIa.
Observation:
- A patient experienced thrombosis of venous anastomoses post-finger replantation.
- The patient exhibited resistance to activated protein C.
Findings:
- The patient was diagnosed with Factor V Leiden mutation.
- This mutation was associated with the observed APC resistance.
Implications:
- This case expands the understanding of APC resistance and Factor V Leiden in surgical contexts.
- Highlights the importance of considering thrombophilia in post-operative vascular complications.
- Suggests potential genetic screening in patients with unusual thrombotic events post-surgery.