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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...

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Related Experiment Video

Updated: Jul 17, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Crohn's-like reaction in diverticular disease

A Gledhill1, M F Dixon

  • 1Department of Histopathology, Harrogate General Hospital, UK.

Gut
|May 13, 1998
PubMed
Summary

Inflammatory changes mimicking Crohn's disease in the colon can be a localized reaction to diverticulitis. This histological finding does not necessarily indicate chronic inflammatory bowel disease in older individuals.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Pathology

Background:

  • Diverticulitis and Crohn's disease can affect the colon in similar locations in older adults.
  • Combined diagnosis may lead to a worse prognosis than individual diseases.
  • Diverticulitis may cause histological changes resembling Crohn's disease without chronic inflammatory bowel disease implications.

Purpose of the Study:

  • To evaluate histological features and clinical outcomes in patients with a combined initial diagnosis of Crohn's colitis and diverticulitis.

Main Methods:

  • Retrospective review of histological specimens from eleven patients undergoing colonic resection.
  • Analysis of case notes and discharge letters for clinical correlation.

Main Results:

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Chronic Salmonella Infection Induced Intestinal Fibrosis

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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

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Last Updated: Jul 17, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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  • Nine out of eleven patients showed a Crohn's-like inflammatory response confined to the diverticular segment.
  • These nine patients had no clinical evidence of Crohn's disease.

Conclusions:

  • A Crohn's-like inflammatory response can be a localized reaction to diverticulitis.
  • This histological pattern does not automatically signify chronic inflammatory bowel disease.