Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Contrast echo imaging on the breast and thyroid cancers]

A Kawauchi1, Y Hashimoto, K Kamiya

  • 1Second Department of Surgery, Showa University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 13, 1998
PubMed
Summary

This review examines how ultrasound contrast agents, specifically SH/TA 508, improve the accuracy of diagnosing breast and thyroid tumors. It highlights the development of advanced imaging techniques like harmonic imaging and acoustic emission mode, which enhance conventional Doppler ultrasound capabilities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabotropic glutamate receptor subtype 7 has critical roles in regulation of the endocrine system and social behaviours.

Journal of neuroendocrinology·2018
Same author

Association between ED and LUTS in Japanese motorcyclists.

International journal of impotence research·2008
Same author

The septal area, site for the central regulation of penile erection during waking and rapid eye movement sleep in rats: a stimulation study.

Neuroscience·2008
Same author

Restless legs syndrome in hemodialysis patients: health-related quality of life and laboratory data analysis.

Clinical nephrology·2006
Same author

Efficacy of sildenafil for Japanese patients with audio-visual sexual stimulation (AVSS) test by the RigiScan Plus.

Archives of andrology·2006
Same author

Do motorcyclists have erectile dysfunction? A preliminary study.

International journal of impotence research·2006

Area of Science:

  • Diagnostic radiology and ultrasound contrast agent research
  • Oncology imaging modalities including breast and thyroid cancer diagnostics

Background:

No prior work had resolved the full diagnostic potential of early ultrasound contrast agents for superficial tumors. It was already known that color Doppler flow mapping provided some utility for differentiating breast and thyroid lesions. That uncertainty drove researchers to investigate specific agents like SH/TA 508. Prior research has shown that these agents undergo rigorous clinical testing phases before widespread implementation. This gap motivated a deeper look into how contrast enhancement might refine existing diagnostic standards. Investigators previously established that safety profiles are paramount when introducing new substances into clinical practice. Early studies often focused on basic flow detection rather than advanced tissue characterization. The field required a synthesis of how these agents influence modern diagnostic imaging evolution.

Purpose Of The Study:

The study aims to evaluate the clinical utility of SH/TA 508 for diagnosing breast and thyroid tumors. This investigation addresses the need for more accurate differential diagnosis in oncology. The authors seek to explain how contrast enhancement refines standard ultrasound procedures. This work explores the transition from basic flow mapping to sophisticated diagnostic techniques. The researchers intend to highlight the safety profile of the agent based on clinical trial outcomes. They address the motivation to improve non-invasive imaging for superficial lesions. This review clarifies the role of new imaging modes in clinical practice. The study provides a clear overview of how contrast agents influence modern diagnostic standards.

Keywords:
color Doppler flow mappingharmonic imagingacoustic emission modetumor differential diagnosis

Frequently Asked Questions

The researchers propose that SH/TA 508 enhances diagnostic accuracy by improving blood flow visualization. Unlike conventional color Doppler, this agent enables the use of harmonic imaging and acoustic emission modes, which provide clearer differentiation between benign and malignant tissue structures in breast and thyroid lesions.

The authors identify harmonic imaging and acoustic emission mode as the primary technical advancements. These methods utilize the unique physical properties of the contrast agent to generate signals that are distinct from background tissue noise, allowing for higher resolution imaging during standard ultrasound examinations.

The researchers state that the agent is necessary to overcome the limitations of standard color Doppler in detecting slow or deep blood flow. Without this enhancement, conventional ultrasound often fails to provide the sensitivity required for accurate differential diagnosis of small or complex tumor masses.

Related Experiment Videos

Main Methods:

Review approach involved a comprehensive synthesis of clinical trial data regarding SH/TA 508. The authors evaluated phase II and III results to determine safety and efficacy. This analysis focused on the transition from conventional flow mapping to advanced modes. The investigators examined how contrast enhancement influences signal processing during standard examinations. They reviewed the development of harmonic imaging as a primary technical outcome. The study assessed the integration of acoustic emission modes into existing ultrasound platforms. This approach prioritized evidence from Japanese clinical trials to support diagnostic claims. The researchers synthesized findings to demonstrate the utility of these agents in oncology.

Main Results:

Key findings from the literature indicate that SH/TA 508 is both safe and effective for tumor assessment. The data confirms that contrast enhancement significantly improves the precision of differential diagnoses. Results demonstrate that this agent enables the successful application of harmonic imaging techniques. The findings show that acoustic emission modes provide superior visualization of vascularity compared to traditional methods. Clinical trials established that these tools perform well across both breast and thyroid lesion types. The evidence suggests that contrast agents are vital for modernizing standard Doppler protocols. Researchers report that the integration of these technologies enhances overall diagnostic confidence. The literature confirms that these advancements represent a major shift in ultrasound capabilities.

Conclusions:

The authors propose that SH/TA 508 serves as a safe and effective tool for clinical tumor assessment. Synthesis and implications suggest that contrast agents significantly improve diagnostic accuracy beyond conventional methods. Researchers indicate that these substances facilitate the creation of sophisticated imaging protocols. The review highlights that harmonic imaging represents a major advancement in visualizing small lesions. Authors maintain that acoustic emission modes provide unique data for differentiating complex tumor structures. The evidence supports the integration of contrast-enhanced ultrasound into standard diagnostic workflows for breast and thyroid conditions. Experts conclude that the synergy between agents and new hardware defines the future of medical imaging. These findings underscore the importance of ongoing technical development in ultrasound diagnostics.

The authors utilize clinical trial data from phases II and III conducted in Japan. This information serves as the foundation for evaluating the safety and efficacy of the agent in human subjects, ensuring that the diagnostic benefits outweigh potential risks during routine medical procedures.

The measurement of diagnostic utility involves comparing contrast-enhanced images against standard non-enhanced ultrasound findings. The researchers observe that the agent consistently improves the visualization of vascular patterns, which is a critical phenomenon for distinguishing between various types of breast and thyroid growths.

The authors suggest that the successful implementation of this agent will lead to broader adoption of contrast-enhanced ultrasound in oncology. They anticipate that these diagnostic improvements will reduce the need for more invasive biopsy procedures by providing more reliable information during initial non-invasive screening sessions.