Related Experiment Videos
Supratentorial giant cell ependymoma: a case report
D F Brown1, D P Chason, L F Schwartz
1Department of Pathology, University of Texas Southwestern Medical School, Dallas 75235-9072, USA.
Summary
This study reports a rare case of supratentorial giant cell ependymoma with anaplastic features. This central nervous system neoplasm presented uniquely with multiple tumor giant cells, a feature typically seen in other brain tumors.
Area of Science:
- Neuro-oncology
- Central Nervous System Pathology
Background:
- Ependymomas are central nervous system neoplasms originating from ependymal cells.
- These tumors can exhibit diverse histological characteristics and occur throughout the neuraxis.
Observation:
- A 26-year-old male presented with right-sided numbness and bifrontal headache.
- Imaging revealed an enhancing mass in the left medial frontal lobe, extending into the lateral ventricle.
Findings:
- Histological, immunohistochemical, and electron microscopy confirmed anaplastic ependymoma.
- The tumor uniquely displayed multiple tumor giant cells, a feature not commonly associated with ependymomas.
Implications:
- This case represents the first documented instance of a supratentorial giant cell ependymoma with anaplastic features.
- The presence of giant cells in this ependymoma subtype expands the known histological spectrum of these central nervous system tumors.