Neuroglia: possible role in thermogenesis and body temperature control

The neuroglia, especially astrocytes, constitute a cell mass capable of adaptive heat production, since both the metabolic substrates and the biochemical machinery for energy production and its regulation seem to be available in these cells. Earlier physiological studies from this laboratory have provided circumstantial evidence that rodents such as rats and rabbits may indeed be capable of increasing their cerebral heat production during acute cold exposure. Recent relevant literature on the ability of neuroglia of the mammalian CNS to synthesize and release different transmitters and modulators and to communicate mutually with neuronal elements is discussed in support of the idea that different glial cell types could also contribute to the central regulation of body temperature in addition to the more established similar function of the neuronal pathways. The present hypothesis may have relevance to changes in glial cell mass and activity that occur in patients during the course of aging, or in gliosis with a consequent tendency for epilepsy caused by head trauma, with a consequent decrease or increase of intracranial metabolic rate, respectively. Also, the possibility for glial contribution to the thermoregulatory changes seen in psychoses is discussed.