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Aspirin-like drugs cause gastrointestinal injuries by metallic cation chelation
1Department of Pathology, Cornell University Medical College, New York, NY 10021, USA. xwang@mail.med.cornell.edu
Medical Hypotheses
|May 13, 1998
Abstract:
Aspirin-like (nonsteroidal anti-inflammatory) drugs may cause injuries including ulcers to the gastrointestinal tract by chelation of the divalent and/or multivalent metallic cations in the gastrointestinal mucus and mucosa, as suggested by the chemical properties of these drugs and supported by experimental and clinical data.