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[Effect of carbon dioxide on peroxynitrite reaction with DNA]
V Ermilov1, Iu Ishio, Kh Oshima
1N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Voprosy Onkologii
|May 14, 1998
Abstract:
Carbon dioxide has been reported to react with peroxynitrite (ONO2CO2-), altering the reactivity characteristic of peroxynitrite. We found that carbon dioxide caused a dose-dependent increase in 8-nitroguanine formation in calf thymus DNA incubated with peroxynitrite, whereas there was not apparent effect on 8-oxoguanine formation. In contrast, carbon dioxide inhibited peroxynitrite-induced strand breakage in plasmid pBR322 DNA and thymine-propenal formation from thymidine.