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Related Experiment Videos

Radiotherapy for non-function pituitary tumours

N J Gittoes1, A S Bates, W Tse

  • 1Department of Medicine, University Hospital Trust, Birmingham, UK. n.j.gittoes@bham.ac.uk

Clinical Endocrinology
|May 14, 1998
PubMed
Summary
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Post-operative radiotherapy significantly reduces non-functioning pituitary tumor regrowth. This adjuvant treatment offers a 93% progression-free survival at 15 years, compared to 33% without radiotherapy.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Endocrinology

Background:

  • Adjuvant pituitary radiotherapy (RT) is common post-surgery for non-functioning pituitary tumors (NFTs).
  • Objective data on RT's efficacy in preventing NFT regrowth is limited.
  • This study evaluates RT's impact on NFT recurrence rates.

Purpose of the Study:

  • To determine if post-operative RT significantly lowers NFT recurrence rates.
  • To compare tumor regrowth in patients who received RT versus those who did not.

Main Methods:

  • Retrospective review of 126 patients with NFTs from two UK institutions.
  • One institution routinely used RT within 12 months of surgery; the other rarely used it.
  • Primary outcome: pituitary tumor regrowth after surgery, comparing RT and non-RT groups.

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Main Results:

  • No significant differences in age, sex, tumor size, or surgical approach between groups.
  • Actuarial progression-free survival at 10 and 15 years was 93% for the RT group.
  • Progression-free survival at 10 and 15 years was 68% and 33% for the non-RT group, respectively.
  • RT administration was the sole significant prognostic factor for reduced NFT regrowth (P < 0.00005).

Conclusions:

  • Pituitary radiotherapy within 12 months of surgery significantly reduces the risk of non-functioning pituitary tumor regrowth.
  • Further research is needed to determine if MRI can identify patients who would benefit most from RT post-surgery.