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Duration of growth suppressive effects of regular inhaled corticosteroids

I J Doull1, M J Campbell, S T Holgate

  • 1Department of Child Health, University Hospital of Wales, Heath Park, Cardiff.

Archives of Disease in Childhood
|May 14, 1998
PubMed

Insights

Regular inhaled corticosteroid use in children temporarily suppresses growth, particularly in the first 18 weeks of treatment. After this period, growth rates normalize, suggesting a transient effect of these asthma medications.

Area of Science:

  • Pediatric Endocrinology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Inhaled corticosteroids (ICS) are a cornerstone of asthma management in children.
  • Concerns exist regarding potential long-term effects of ICS on growth velocity.

Purpose of the Study:

  • To quantify the impact of regular inhaled corticosteroid treatment on the growth of children.
  • To determine the temporal pattern of growth suppression associated with inhaled corticosteroid initiation.

Main Methods:

  • A cohort of 50 children receiving regular ICS was studied.
  • Growth data was analyzed in six-week intervals post-treatment initiation.
  • A random effects regression model compared growth during ICS treatment versus non-treatment periods.

Main Results:

  • Significant growth suppression was observed, most pronounced within the initial 18 weeks of ICS therapy.
  • Growth rates returned to baseline levels comparable to non-treatment periods after the initial 18 weeks.
  • The magnitude of suppression varied, with the most substantial impact noted early in the treatment course.

Conclusions:

  • Inhaled corticosteroid treatment in children leads to a temporary, but significant, reduction in growth velocity.
  • The most critical period for monitoring growth is the initial 18 weeks of therapy.
  • These findings necessitate careful consideration of treatment initiation and monitoring strategies for pediatric asthma management.

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