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Related Experiment Videos

Hemostasis and malignancy

J L Francis1, J Biggerstaff, A Amirkhosravi

  • 1Division of Cell Biology, Hemostasis and Thrombosis Research, Walt Disney Memorial Cancer Institute at Florida Hospital, Altamonte Springs 32701, USA.

Seminars in Thrombosis and Hemostasis
|May 14, 1998
PubMed
Summary
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The hemostatic system, involving blood clotting, plays a role in cancer growth and spread. Targeting this system with antihemostatic agents shows promise in treating experimental tumors and is being explored in human clinical trials.

Area of Science:

  • Oncology
  • Hematology
  • Biochemistry

Background:

  • The hemostatic system is increasingly recognized for its role in cancer progression.
  • Thromboembolic disease and hemostatic abnormalities are common in cancer patients.
  • Antihemostatic agents have shown efficacy in experimental tumor models.

Purpose of the Study:

  • To explore the involvement of the hemostatic system in malignant disease growth and metastasis.
  • To investigate the mechanisms by which hemostatic activation facilitates cancer progression.
  • To highlight the potential roles of specific proteins like tissue factor and urokinase receptor in metastasis.

Main Methods:

  • Review of existing evidence on hemostatic system involvement in cancer.
  • Analysis of studies on antihemostatic agents in experimental and clinical settings.

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  • Examination of molecular mechanisms, including tissue factor and urokinase receptor functions.

    • Main Results:

    • Hemostatic abnormalities are prevalent in cancer patients, with increased thromboembolic events.
    • Intravascular coagulation and fibrin deposition are implicated in cancer metastasis.
    • Tissue factor and urokinase receptor on malignant cells may drive metastasis and neovascularization.

    Conclusions:

    • The hemostatic system is a significant factor in cancer growth and spread.
    • Further elucidation of hemostatic activation mechanisms is crucial for cancer therapy.
    • Tissue factor may possess functions beyond coagulation critical to solid tumor biology.