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Anticonvulsant action of gabapentin during postnatal development in rats
1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Purpose:
To study the anticonvulsant effects of gabapentin (GBP) in immature animals.
Methods:
Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizures [minimal (i.e., clonic)] and generalized tonic-clonic (GTCS) were recorded, and seizure severity was scored.
Results:
GBP suppressed or at least restricted the tonic phase of GTCS at all the developmental stages studied. In addition, minimal seizures were suppressed in 18-day-old rats. Both effects exhibited a tendency to a U-shaped dose-response curve.
Conclusions:
Anticonvulsant effects of GBP were demonstrated in immature and in adult rats.