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[Lupus nephropathy treated with cyclosporine A. Report of 3 cases]
M García Gasalla1, M Yebra Bango, J A Vargas Núñez
1Servicio de Medicina Interna I, Clínica Puerta de Hierro, Madrid.
Abstract:
Three patients are reported who had systemic lupus erythematosus and membrane-proliferative glomerulonephritis. These patients failed to respond to intravenous cyclophosphamide and steroids and were then changed to receive oral cyclosporine A, at a dose of 5 mg/kg/day. The three patients showed remission of disease, symptoms, and renal and immunological parameters, with minimal secondary effects. The medical literature was reviewed and cyclosporine A is suggested to be a therapeutical choice for patients with lupus nephropathy even when they do not respond to other immunosuppressive regimes, such as pulse cyclophosphamide.
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