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[Isoxsuprine in hypertension during pregnancy]
J C Briones-Garduño1, R González-Alvarez
1Centro Médico La Raza, Instituto Mexicano del Seguro Social, México, D.F.
Gaceta Medica De Mexico
|May 15, 1998
Summary
Isoxsuprine effectively lowers blood pressure in pregnant patients with severe toxemia or preeclampsia. This treatment shows no adverse effects on the mother-fetus binomial, making it a safe and manageable option.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Background:
- Hypertension in pregnancy, including preeclampsia and severe toxemia, poses significant risks to both mother and fetus.
- Effective and safe management of hypertensive disorders in pregnancy is crucial for improving maternal and fetal outcomes.
Purpose of the Study:
- To evaluate the efficacy and safety of isoxsuprine as a hypotensive agent in pregnant patients with severe toxemia or preeclampsia.
- To assess the impact of isoxsuprine on maternal and fetal well-being, including heart rate and Apgar scores.
Main Methods:
- A study involving 50 pregnant patients (≥24 weeks gestation) diagnosed with severe toxemia or preeclampsia.
- Administration of isoxsuprine (50 mg in 250 ml D5W) and evaluation of hypotensive effects, maternal-fetal heart rates, and Apgar scores post-delivery.
Main Results:
- Isoxsuprine demonstrated a significant decrease in arterial blood pressure within 15 minutes of administration.
- Average dose of 9 drops (0.29 mcg/min) was effective in reducing hypertension.
- No adverse effects were observed on maternal-fetal heart rate, Apgar scores, glycemia, or obstetric bleeding.
Conclusions:
- Isoxsuprine is an effective, rapid-acting, and easily managed hypotensive agent for treating hypertension in pregnancy.
- The drug exhibits a favorable safety profile with no detrimental effects on the mother-fetus binomial.