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Related Experiment Videos

Behavioral and monoaminergic changes after lindane exposure in developing rats

S Rivera1, R Rosa, E Martínez

  • 1Department of Pharmacology and Toxicology, IIBB, CSIC, Barcelona, Spain.

Neurotoxicology and Teratology
|May 15, 1998
PubMed
Summary

Lindane exposure in rat pups alters behavior and brain chemistry. Both single and repeated doses affected passive avoidance and motor activity, impacting central monoaminergic systems.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Developmental Biology

Background:

  • Lindane is an organochlorine insecticide.
  • Exposure during development can lead to neurotoxicity.
  • Understanding its effects on the developing brain is crucial.

Purpose of the Study:

  • To investigate the behavioral and neurochemical effects of lindane in developing rats.
  • To examine the impact of acute versus repeated lindane administration on monoaminergic systems.

Main Methods:

  • Postnatal day 15 rat pups were administered lindane orally (single 20 mg/kg or repeated 10 mg/kg for 7 days).
  • Behavioral tests included passive avoidance acquisition and motor activity.
  • Central monoaminergic systems were analyzed by measuring neurotransmitter and metabolite ratios (e.g., 5-HIAA/serotonin, DOPAC/dopamine).

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Main Results:

  • Both lindane treatment schedules enhanced passive avoidance acquisition.
  • Acute lindane decreased motor activity, while repeated dosing increased it.
  • Lindane altered monoamine/metabolite ratios in various brain regions, suggesting changes in neurotransmitter turnover, with specific regional effects correlating to behavioral changes.

Conclusions:

  • Lindane exposure in early development disrupts central monoaminergic systems.
  • Both acute and repeated lindane doses induce distinct behavioral alterations.
  • The observed behavioral changes may result from an imbalance in monoaminergic systems and lindane's GABAergic blockade.