Related Experiment Videos
Eccrine porocarcinoma with melanocyte colonization
Y Nakanishi1, Y Matsuno, T Shimoda
1Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
The British Journal of Dermatology
|May 15, 1998
Summary
This case study details a pigmented eccrine porocarcinoma, a rare skin cancer, found on a patient's leg. The tumor showed no recurrence after ten months, indicating a potentially favorable prognosis.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Eccrine porocarcinoma is a rare malignant adnexal tumor originating from the intraepidermal eccrine duct.
- Pigmented variants are exceptionally uncommon, posing diagnostic challenges.
Observation:
- A 74-year-old Japanese man presented with a 9x7 mm brown-black nodule on his leg.
- Microscopic examination revealed a dermal-invasive tumor composed of poroid cells with intracytoplasmic lumina, cytological pleomorphism, and abnormal mitotic figures.
- Dendritic melanocytes containing melanin were interspersed within the tumor nests.
Findings:
- Immunohistochemistry confirmed poroid cells positive for cytokeratin.
- Melanin-containing dendritic cells were positive for S-100 protein and HMB-45.
- The tumor invaded the reticular dermis.
Implications:
- This case highlights the histological and immunohistochemical features of pigmented eccrine porocarcinoma.
- Early diagnosis and complete excision are crucial for managing this rare malignancy.
- The absence of recurrence at 10 months suggests a potentially good outcome with adequate treatment.