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Elevated plasma lipoprotein(a) is associated with coronary artery disease in patients with chronic stable angina

R A Schwartzman1, I D Cox, J Poloniecki

  • 1Department of Cardiological Sciences, St. George's Hospital Medical School, London, England, United Kingdom.

Journal of the American College of Cardiology
|May 15, 1998
PubMed

Insights

Elevated lipoprotein(a) [Lp(a)] levels are linked to coronary artery disease (CAD) in stable angina patients. This finding highlights Lp(a) as an independent risk factor, particularly significant in women.

Area of Science:

  • Cardiology
  • Lipid Metabolism
  • Atherosclerosis Research

Background:

  • The association between plasma lipoprotein(a) [Lp(a)] levels and the severity of coronary artery disease (CAD) in stable angina patients remains under-investigated.
  • Previous studies have not comprehensively evaluated this relationship in well-characterized patient cohorts.

Purpose of the Study:

  • To determine the relationship between plasma Lp(a) levels and clinical variables in patients with chronic stable angina.
  • To assess the association between Lp(a) levels and angiographically determined coronary artery disease (CAD).

Main Methods:

  • Investigated 129 consecutive white patients (43 women) undergoing coronary angiography for chronic stable angina.
  • Analyzed clinical variables, lipid profiles, and angiographic scores.
  • Utilized multiple logistic regression to identify independent predictors of CAD.

Main Results:

  • Patients with significant angiographic stenoses (> or =70%) had significantly higher plasma Lp(a) levels compared to those without.
  • Elevated Lp(a) was independently predictive of significant angiographic stenoses, even after excluding patients on lipid-lowering treatment.
  • The association between Lp(a) and CAD was particularly significant in women.

Conclusions:

  • Elevated plasma Lp(a) is an independent risk factor for angiographic coronary artery disease (CAD) in patients with chronic stable angina.
  • Plasma Lp(a) may hold particular significance as a risk factor for CAD in women.
  • These findings underscore the importance of assessing Lp(a) levels in the risk stratification of patients with stable angina.
Abstract

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