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Related Experiment Videos

Is coffee a colonic stimulant?

S S Rao1, K Welcher, B Zimmerman

  • 1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA.

European Journal of Gastroenterology & Hepatology
|May 15, 1998
PubMed
Summary
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Coffee, both caffeinated and decaffeinated, stimulates colonic motor activity. Caffeinated coffee

Area of Science:

  • Gastroenterology and Digestive Health
  • Human Physiology

Background:

  • The impact of coffee consumption on colonic function remains unclear.
  • The specific role of caffeine in coffee's effect on the colon is not well-defined.

Purpose of the Study:

  • To investigate the effects of coffee, both caffeinated and decaffeinated, on colonic motor activity in healthy individuals.
  • To compare the colonic response to coffee with that of water and a meal.

Main Methods:

  • Ambulatory colonic manometry using a six-sensor probe in 12 healthy subjects.
  • Administration of black Colombian coffee (150 mg caffeine), decaffeinated coffee, water, and a 1000 kcal meal over 10 hours.
  • Analysis of colonic motor responses, including pressure wave area and propagated contractions.

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Main Results:

  • Caffeinated coffee, decaffeinated coffee, and a meal significantly increased colonic motor activity compared to water (P < 0.01).
  • All three stimuli induced greater motor activity in the transverse/descending colon than in the rectosigmoid colon (P < 0.05).
  • Decaffeinated coffee showed no significant difference in colonic motility compared to water or caffeinated coffee, but was less potent than a meal (P < 0.05).

Conclusions:

  • Caffeinated coffee stimulates colonic motor activity.
  • The magnitude of stimulation by caffeinated coffee is comparable to a meal.
  • Coffee's effect on colonic motility is significantly stronger than water and slightly stronger than decaffeinated coffee.