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Heterotheca inuloides: anti-inflammatory and analgesic effect

R M Gené1, L Segura, T Adzet

  • 1Unitat de Farmacologia i Farmacognosia, Facultat de Farmàcia, Universitat de Barcelona, Spain.

Journal of Ethnopharmacology
|May 15, 1998
PubMed
Summary

The butanol fraction (HI-2) from Heterotheca inuloides flowers shows significant anti-inflammatory and analgesic effects. This fraction effectively reduced inflammation and pain in animal models, validating its traditional medicinal use.

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Area of Science:

  • Pharmacology
  • Ethnobotany
  • Natural Products Chemistry

Background:

  • Heterotheca inuloides Cass. (Asteraceae) is a plant with a history of use in Mexican traditional medicine.
  • Scientific validation of its anti-inflammatory properties is needed.

Purpose of the Study:

  • To evaluate the anti-inflammatory and analgesic activities of Heterotheca inuloides flower extracts.
  • To identify the most active fraction and characterize its effects.

Main Methods:

  • Aqueous extract of H. inuloides flowers was fractionated into ethyl ether (HI-1), butanol (HI-2), and aqueous (HI-3) fractions.
  • Anti-inflammatory activity was assessed using carrageenan-, dextran-, and arachidonic acid-induced edema tests.
  • Analgesic activity was evaluated through acetic acid-induced abdominal constrictions.

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  • Ulcerogenic potential was assessed in a standard assay.

    • Main Results:

    • The butanol fraction (HI-2) demonstrated significant anti-inflammatory activity, with 58.0% inhibition in the carrageenan test and an ED50 of 29.7 mg/kg.
    • HI-2 also showed potent analgesic effects, inhibiting acetic acid-induced abdominal constrictions by 73.8-78.2%.
    • HI-2 exhibited anti-inflammatory effects against dextran-induced edema but not zymosan or C16-paf-induced edema, and showed a low ulcerogenic index.

    Conclusions:

    • The butanol fraction (HI-2) of Heterotheca inuloides possesses significant anti-inflammatory and analgesic properties.
    • These findings support the traditional medicinal use of H. inuloides for inflammatory conditions and pain relief.