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Related Experiment Videos

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

R A Greenberg1, R C Allsopp, L Chin

  • 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Oncogene
|May 15, 1998
PubMed
Summary

Researchers identified the mouse telomerase reverse transcriptase (mTERT) component, showing its similarity and functional interchangeability with human TERT. mTERT expression, unlike human TERT, is widespread in mouse cells, potentially explaining higher spontaneous immortalization and tumorigenesis rates.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Telomerase is a key enzyme in maintaining telomere length.
  • The catalytic subunit of telomerase, TERT, is essential for its function.
  • Understanding TERT's role in different species is crucial for cancer research.

Purpose of the Study:

  • To identify and characterize the mouse telomerase reverse transcriptase component (mTERT).
  • To investigate the functional relationship between mTERT and human TERT (hTERT).
  • To explore the expression patterns and regulation of mTERT in mouse tissues and cells.

Main Methods:

  • Sequence homology analysis between mTERT and hTERT.
  • In vitro telomerase reconstitution experiments using mTERT and hTR.

Related Experiment Videos

  • Quantitative analysis of mTERT and mTR mRNA levels in various mouse tissues and cell types.
  • Comparison of mTERT expression with telomerase activity during differentiation and proliferation.

    • Main Results:

    • mTERT shares significant sequence homology and conserved motifs with hTERT.
    • mTERT is functionally interchangeable with hTERT, reconstituting telomerase activity with hTR.
    • mTERT is widely expressed in adult mouse tissues, particularly during embryogenesis, thymus, and intestine.
    • mTERT mRNA levels are regulated during differentiation and proliferation, correlating more closely with telomerase activity than mTR levels.
    • Unlike human cells, mTERT is readily detectable in primary mouse cells and not upregulated post-crisis.

    Conclusions:

    • mTERT is a functional homolog of hTERT with conserved enzymatic activity.
    • The widespread expression of mTERT in mouse tissues and primary cells may contribute to higher spontaneous immortalization and tumorigenesis rates compared to humans.