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Related Experiment Videos

Decrease in circulating and urine adrenomedullin concentrations in stroke-prone spontaneously hypertensive rats

S Hirano1, Y Ishiyama, T Matsuo

  • 1First Department of Internal Medicine, Miyazaki Medical College, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|May 15, 1998
PubMed
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Low circulating adrenomedullin (AM) levels may contribute to high blood pressure in stroke-prone spontaneously hypertensive rats. This suggests accelerated AM metabolism may be a factor in maintaining hypertension.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Hypertension Research

Background:

  • Adrenomedullin (AM) is a peptide hormone known for its vasodilatory and hypotensive effects.
  • Elevated plasma AM levels are observed in various models of experimental hypertension.
  • Previous studies showed similar plasma AM levels in spontaneously hypertensive rats (SHR) and normotensive controls.

Purpose of the Study:

  • To investigate the role of AM in severe hypertension by examining circulating and tissue AM levels in stroke-prone spontaneously hypertensive rats (SHRSP/Izm).
  • To compare AM levels and expression in SHRSP/Izm with age-matched Wistar-Kyoto rats (WKY/Izm).

Main Methods:

  • Quantification of immunoreactive rat AM in plasma and urine using radioimmunoassay.
  • Measurement of AM mRNA levels in various tissues.

Related Experiment Videos

  • Analysis of plasma AM molecular components via reverse-phase high-performance liquid chromatography.
  • Comparison between 15-week-old SHRSP/Izm and WKY/Izm rats.

    • Main Results:

    • Plasma and urinary AM levels were significantly lower in SHRSP/Izm compared to WKY/Izm.
    • A negative correlation was observed between plasma AM levels and systolic blood pressure in both rat groups.
    • Molecular composition of plasma AM was similar between SHRSP/Izm and WKY/Izm.
    • Tissue AM levels were not lower in SHRSP/Izm compared to WKY/Izm.

    Conclusions:

    • Low circulating AM levels may contribute to the maintenance of high blood pressure in 15-week-old SHRSP/Izm.
    • Accelerated metabolism of circulating AM is a potential cause for the reduced plasma AM levels observed in SHRSP/Izm.