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Compatibility of ketamine and morphine injections
M H Lau1, C Hackman, D J Morgan
1Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Australia.
Pain
|May 16, 1998
Summary
Ketamine and morphine mixtures are stable for 24 hours. Adjusting the pH to minimize irritation did not affect the stability of these pharmaceutical compounds.
Area of Science:
- Pharmacology
- Pharmaceutical Chemistry
Background:
- Ketamine and morphine are often used together in clinical settings.
- Ensuring the stability of drug mixtures is crucial for safe and effective administration.
Purpose of the Study:
- To evaluate the chemical compatibility and stability of ketamine and morphine mixtures.
- To determine the impact of pH adjustment on the stability of this drug combination.
Main Methods:
- The stability of ketamine and morphine mixtures was assessed over a 24-hour period.
- pH levels were adjusted to minimize potential local tissue irritation.
Main Results:
- Ketamine and morphine mixtures demonstrated stability over the 24-hour study duration.
- pH adjustment to levels as low as 5.9 did not compromise the stability of the mixture.
Conclusions:
- Ketamine and morphine mixtures are chemically stable for at least 24 hours.
- The pH can be adjusted to improve tolerability without sacrificing drug stability.