Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interruption of bronchial circulation leads to a severe decrease in peribronchial oxygen tension in standard lung

U Herold1, H Jakob, M Kamler

  • 1Department of Cardiac Surgery, University of Heidelberg, Germany.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|May 16, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial.

Anaesthesia·2024
Same author

[Update in lung transplantation].

Zeitschrift fur Herz-, Thorax- und Gefasschirurgie·2020
Same author

Magnetic resonance imaging-guided transurethral ultrasound ablation of prostate tissue in patients with localized prostate cancer: single-center evaluation of 6-month treatment safety and functional outcomes of intensified treatment parameters.

World journal of urology·2019
Same author

Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.

Molecular metabolism·2018
Same author

Changes in serum KL-6 levels are associated with the development of chronic lung allograft dysfunction in lung transplant recipients.

Transplant immunology·2018
Same author

Histidine metabolism after Bretschneider cardioplegia in cardiac surgical patients.

Physiological research·2018

Lung transplantation leads to low peribronchial oxygen, impacting healing. Nitric oxide did not improve oxygen levels, suggesting central venous oxygen is key for post-transplant recovery.

Area of Science:

  • Cardiovascular and Respiratory System Physiology
  • Transplantation Medicine
  • Surgical Innovation

Background:

  • Lung transplantation uniquely severs bronchial artery perfusion, creating abnormal physiology.
  • Nutritive support relies on collateral pulmonary artery flow and desaturated venous blood.
  • This compromised oxygen supply to the bronchial tissue is a critical clinical concern.

Purpose of the Study:

  • To systematically analyze peribronchial tissue oxygen tension after single left lung transplantation.
  • To investigate the effect of nitric oxide (NO) on augmenting collateral blood flow and oxygenation.
  • To determine the relationship between pulmonary artery flow, central venous oxygen, and peribronchial tissue oxygen tension.

Main Methods:

  • Utilized a standard pig model for single left lung transplantation (n=12).

Related Experiment Videos

  • Lung preservation followed clinical standards with modified Euro-Collins solution and prostacyclin for 4-hour ischemia.
  • Measured peribronchial and myocardial tissue oxygen tension (Licox probes) and pulmonary artery flow (ultrasound probes) pre- and post-transplant.

    • Main Results:

    • Single lung transplantation significantly decreased peribronchial tissue oxygen tension in both control and NO-treated groups (38.3 to ~10 mmHg).
    • Nitric oxide administration increased left pulmonary artery flow but did not improve peribronchial tissue oxygen tension.
    • Central venous pO2 remained stable and comparable to pre-transplant levels, unaffected by NO or increased pulmonary flow.

    Conclusions:

    • Low peribronchial tissue oxygen tension post-lung transplantation persists and is linked to central venous pO2, not improved pulmonary artery flow.
    • Nitric oxide does not enhance peribronchial oxygenation in this model.
    • Compromised peribronchial oxygenation may contribute to anastomotic healing issues, infections, and obliterative bronchiolitis.