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Cytotoxic scalarane sesterterpenes from a sponge, Hyrtios erecta
1Biomedical Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
Journal of Natural Products
|May 19, 1998
Abstract:
Novel scalarane sesterterpenes (1-4) were isolated from a sponge, Hyrtios erecta (order Dictyoceratida). They were characterized by means of spectral analyses, X-ray crystallography, and chemical reactions. Compound 1 showed potent in vitro and in vivo antitumor activities. In addition, the structure-activity relationship was also discussed using computer-assisted structure matching of 1 and aragusterols.