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Updated: Jul 24, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

[Blood pressure and diastolic function in the elderly]

H Odawara1, T Chikamori, T Yabe

  • 1Department of Medicine and Geriatrics, Kochi Medical School.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|May 19, 1998
PubMed

Insights

Blood pressure is linked to heart diastolic function in older adults. This relationship is stronger during sleep, highlighting the importance of monitoring blood pressure overnight for elderly cardiovascular health.

Area of Science:

  • Cardiology
  • Gerontology
  • Physiology

Context:

  • Assessing the relationship between blood pressure and cardiac diastolic function in the elderly is crucial for understanding cardiovascular health in aging populations.
  • Previous studies have shown mixed results regarding the correlation between casual blood pressure and diastolic indices.

Purpose:

  • To investigate the association between blood pressure and diastolic function in elderly individuals.
  • To determine if ambulatory blood pressure monitoring provides a stronger correlation with diastolic function compared to casual measurements.

Summary:

  • This study involved 28 healthy elderly volunteers who underwent blood pressure measurements (casual and ambulatory) and cardiac imaging (echocardiography and radionuclide angiography).
  • Casual blood pressure showed limited correlation with diastolic function indices, except for peak filling rate during atrial contraction (r = 0.39, p < 0.05).
  • Ambulatory blood pressure monitoring revealed significant correlations between peak filling rate during atrial contraction and 24-hour, awake, and sleep blood pressure. The strongest correlation was observed between sleep blood pressure and peak filling rate during atrial contraction (r = 0.53, p < 0.005).

Impact:

  • These findings demonstrate a direct relationship between blood pressure and diastolic function in the elderly.
  • The correlation is significantly stronger during sleep, suggesting that nocturnal blood pressure plays a critical role in maintaining diastolic function in older adults.
  • This highlights the potential clinical significance of monitoring sleep blood pressure for assessing and managing diastolic dysfunction in the elderly.

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