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Substance dependence as a compulsive behavior

G F Koob1, M Rocio, A Carrera

  • 1Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA. GKOOB@scripps.edu

Journal of Psychopharmacology (Oxford, England)
|May 19, 1998
PubMed
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Addiction involves compulsive drug seeking and loss of control. This study redefines loss of control in animal models, identifying multiple reinforcement sources contributing to drug dependence.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pharmacology

Background:

  • Substance dependence (addiction) is characterized by compulsive drug use and impaired control over intake.
  • Existing animal models struggle to fully capture the complexity of addiction's behavioral syndrome.
  • Defining 'loss of control' and 'compulsive drug taking' in preclinical research remains challenging.

Purpose of the Study:

  • To redefine 'loss of control' in addiction within the context of animal models.
  • To identify and model various reinforcement sources contributing to drug-seeking behavior.
  • To explore the neurobiological underpinnings of addiction's behavioral components.

Main Methods:

  • Conceptual redefinition of 'loss of control' as a narrowed behavioral repertoire focused on drug seeking.

Related Experiment Videos

  • Review and presentation of evidence from separate animal models for addiction criteria.
  • Examination of neurochemical system alterations due to chronic drug exposure.

    • Main Results:

    • Loss of control is proposed to manifest as a focused behavioral repertoire on drug-seeking.
    • Multiple sources of reinforcement, including neurochemical changes from chronic drug use, contribute to this focus.
    • Separate animal models exist for various addiction criteria and reinforcement sources.

    Conclusions:

    • The study offers a refined conceptual framework for understanding addiction in animal models.
    • Further research is needed to elucidate the neurobiological substrates of addiction's behavioral components.
    • Development of improved animal models is crucial for advancing addiction research.