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Zolpidem tolerance and dependence--two case reports

A Ravishankar¹, T Carnwath

¹Moorside, Trafford General Hospital, Urmston, Manchester, UK.

Journal of Psychopharmacology (Oxford, England)

|May 19, 1998

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This study reports two cases of zolpidem tolerance and dependence, highlighting the potential for misuse of this common sleep medication. Further research is needed to understand and prevent zolpidem abuse.

Area of Science:

Pharmacology
Clinical Medicine
Addiction Psychiatry

Background:

Zolpidem is a widely prescribed sedative-hypnotic medication used for insomnia.
While generally considered safe for short-term use, concerns regarding tolerance and dependence exist.

Observation:

Two distinct cases of individuals developing tolerance and dependence on zolpidem are presented.
These cases illustrate the clinical manifestation of problematic zolpidem use.

Findings:

The reported cases suggest that zolpidem can lead to tolerance and dependence, similar to other sedative-hypnotic drugs.
A review of existing literature reveals other instances of zolpidem misuse and dependence.

Implications:

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These findings underscore the importance of monitoring zolpidem use and considering the potential for abuse.

Clinicians should be aware of the risks associated with long-term zolpidem prescription and explore alternative treatments if dependence is suspected.