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Related Experiment Videos

Epidermal oxidative stress in vitiligo

S Passi1, M Grandinetti, F Maggio

  • 1Centro Invecchiamento Cellulare, Istituto Dermopatico dell'Immacolata (IRCCS), Roma, Italy.

Pigment Cell Research
|May 19, 1998
PubMed
Summary

Active vitiligo (AVP) is linked to lower levels of key antioxidants like ubiquinol (CoQ10H2) and vitamin E (Vit E). This antioxidant deficiency contributes to oxidative stress and skin cell damage in vitiligo patients.

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Area of Science:

  • Dermatology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Vitiligo is a condition characterized by depigmentation of the skin.
  • Oxidative stress is implicated in the pathogenesis of various skin disorders.
  • The role of antioxidants in the epidermis of active vitiligo patients requires further elucidation.

Purpose of the Study:

  • To investigate epidermal levels of enzymatic and non-enzymatic antioxidants in active vitiligo patients.
  • To assess the association between antioxidant levels and polyunsaturated fatty acids in vitiligo epidermis.
  • To determine if oxidative stress plays a role in the epidermal changes observed in vitiligo.

Main Methods:

  • Quantification of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), vitamin E (Vit E), ubiquinol (CoQ10H2), reduced glutathione (GSH), and oxidized glutathione in epidermal samples.

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  • Analysis of phospholipid polyunsaturated fatty acids (PL-PUFA) in epidermal samples.
  • Comparison of antioxidant levels and PL-PUFA profiles between 15 active vitiligo patients and 15 healthy controls.

    • Main Results:

    • Significantly reduced epidermal levels of ubiquinol (CoQ10H2), vitamin E (Vit E), reduced glutathione (GSH), and catalase (CAT) activity were observed in active vitiligo patients.
    • A marked increase in oxidized glutathione was noted in vitiligo patients.
    • Deficiency in lipophilic antioxidants (CoQ10H2, Vit E) correlated with reduced PL-PUFA, suggesting lipoperoxidation.

    Conclusions:

    • The epidermis of active vitiligo patients exhibits an imbalance in intracellular redox status.
    • Significant depletion of both enzymatic and non-enzymatic antioxidants characterizes vitiligo epidermis.
    • These findings indicate abnormal oxidative stress contributing to epidermal cell injury in vitiligo.