Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tracheal intubation with rocuronium using the "timing principle"

T J Sieber1, A M Zbinden, M Curatolo

  • 1Department of Anesthesia and Intensive Care, University Hospital Bern, Switzerland. tomsieber@compuserve.com

Anesthesia and Analgesia
|May 19, 1998
PubMed
Summary

Rocuronium, administered using the "timing principle," provides excellent endotracheal intubating conditions comparable to succinylcholine. This method involves giving the muscle relaxant at the onset of clinical weakness before the anesthetic drug.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of <math></math> production with the hadronically decaying boson reconstructed as one or two jets in <i>pp</i> collisions at <math> </math> with ATLAS, and constraints on anomalous gauge couplings.

The European physical journal. C, Particles and fields·2020
Same author

Study of <math></math> and <math></math> production in <math></math> collisions at <math> </math> and search for anomalous quartic gauge couplings with the ATLAS experiment.

The European physical journal. C, Particles and fields·2020
Same author

Identification and rejection of pile-up jets at high pseudorapidity with the ATLAS detector.

The European physical journal. C, Particles and fields·2020
Same author

Measurement of detector-corrected observables sensitive to the anomalous production of events with jets and large missing transverse momentum in <math></math> collisions at <math> </math>  TeV using the ATLAS detector.

The European physical journal. C, Particles and fields·2020
Same author

Measurement of lepton differential distributions and the top quark mass in <math></math> production in <i>pp</i> collisions at <math> </math>  TeV with the ATLAS detector.

The European physical journal. C, Particles and fields·2020
Same author

Search for direct top squark pair production in final states with two leptons in <math> </math> TeV <i>pp</i> collisions with the ATLAS detector.

The European physical journal. C, Particles and fields·2020

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Endotracheal intubation is a critical procedure in anesthesia.
  • Optimizing intubating conditions is essential for patient safety and procedural success.
  • The
  • timing principle
  • offers a novel approach to administering neuromuscular blocking agents.

Purpose of the Study:

  • To compare endotracheal intubating conditions using rocuronium with the
  • timing principle
  • versus succinylcholine.
  • To evaluate the efficacy of rocuronium at different time points (45 and 60 seconds) after induction with thiopental.

Main Methods:

  • A randomized study involving 45 patients assigned to three groups.
  • Groups 1 and 2 received rocuronium (0.6 mg/kg) followed by thiopental induction at the onset of ptosis, with intubation at 45s (Group 1) and 60s (Group 2).

Related Experiment Videos

  • Group 3 received vecuronium (0.01 mg/kg) 3 minutes prior to thiopental and succinylcholine (1.5 mg/kg) with intubation at 60s.

    • Main Results:

    • All patients in all groups experienced either good or excellent intubating conditions.
    • Rocuronium (0.6 mg/kg) administered via the
    • timing principle
    • resulted in good to excellent intubating conditions at both 45 and 60 seconds.
    • Postoperative interviews revealed patient satisfaction with the anesthetic induction across all groups.

    Conclusions:

    • Rocuronium, when used with the
    • timing principle
    • , is effective in providing good to excellent endotracheal intubating conditions.
    • The timing of rocuronium administration relative to anesthetic induction impacts intubating conditions.
    • No significant difference in intubating conditions was observed between the rocuronium-based timing principle and the standard succinylcholine technique.