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Preparation of thietane derivatives from 2-(3-hydroxyalkylthio)benzoxazoles and their conversion into thietane
D Ikemizu1, A Matsuyama, T Endo
1Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University, Tokyo, Japan.
Nucleic Acids Symposium Series
|January 1, 1997
Abstract:
Thietanes were prepared by the reaction of 2-(3-hydroxyalkylthio)benzoxazoles with KH. 3,3-Dibenzylthietane was oxidized by mCPBA to give 3,3-dibenzylthietane-1-oxide, which was converted into thietane nucleosides (Pummerer-type-reaction).