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Mechanistic analogy between metal ion-catalyzed self-splicing of protein and RNA
T Takarada1, A Yamamura, M Yashiro
1Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Japan.
Nucleic Acids Symposium Series
|January 1, 1997
Abstract:
Recent studies have shown that RNA hydrolysis is remarkably promoted by metal ions and suitably designed metal complexes. We have found that autocleavage of dipeptides X-Ser and a tripeptide Gly-Ser-Ala is catalyzed by Zn(II) at 70 degrees C and pH 7.0. A mechanistic analogy between metal ion-catalyzed hydrolysis of peptides and RNA is suggested.