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[Influence of nosocomial infection on mortality in an intensive care unit]

C Díaz Molina1, D Martínez de la Concha, I Salcedo Leal

  • 1Servicio de Medicina Preventiva, Hospital Universitario Reina Sofía, Córdoba.

Gaceta Sanitaria
|May 20, 1998
PubMed
Abstract

Insights

Nosocomial infections (NI) in Intensive Care Unit (ICU) patients increase mortality risk, especially in those with lower severity scores. The impact of NI on mortality diminishes as patient illness severity increases.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Context:

  • Intensive Care Units (ICUs) are critical settings for severe illness management.
  • Nosocomial infections (NI) pose a significant threat to patient outcomes in ICUs.
  • Understanding factors influencing ICU mortality is crucial for improving patient care.

Purpose:

  • To investigate the relationship between nosocomial infections (NI) and mortality in Intensive Care Unit (ICU) patients.
  • To adjust for other mortality predictors in evaluating the impact of NI.
  • To determine how patient severity influences the association between NI and mortality.

Summary:

  • A prospective study analyzed 944 ICU patients, finding an 11.2% mortality rate.
  • Nosocomial infections (NI) were associated with a crude mortality relative risk of 2.2.
  • Multivariable analysis revealed that NI's effect on mortality varied by APACHE II score; NI increased risk in less severe patients but was less relevant in highly severe cases.

Impact:

  • This study confirms the association between NI and mortality in ICU patients, even after accounting for other prognostic factors.
  • Findings highlight the importance of considering patient severity when assessing the impact of NI on ICU mortality.
  • Results underscore the need for effective infection control strategies in ICUs to mitigate mortality risks.

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