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Hypopituitarism and antiphospholipid syndrome
C Pandolfi1, A Gianini, V Fregoni
1Dipartimento di Endocrinologia, Ospedale Maggiore, Lodi.
Minerva Endocrinologica
|May 20, 1998
Summary
Vascular damage can cause hypopituitarism. This case highlights anterior hypopituitarism as a new endocrine complication of antiphospholipid syndrome (APS) following stroke.
Area of Science:
- Endocrinology
- Vascular Medicine
- Rheumatology
Background:
- Vascular damage is a known cause of hypopituitarism.
- Antiphospholipid syndrome (APS) involves thrombosis but has limited reported endocrine involvement (Addison's disease).
Observation:
- A 62-year-old woman with antiphospholipid syndrome (APS) and atrial thrombosis developed global anterior pituitary insufficiency after a cerebral ischemic stroke.
- Underlying causes for pituitary insufficiency were ruled out.
Findings:
- This is the first reported case of anterior hypopituitarism in the context of antiphospholipid syndrome (APS).
- It represents the second endocrine complication described for APS.
Implications:
- This case expands the known endocrine manifestations of antiphospholipid syndrome (APS).
- It underscores the importance of considering pituitary function in APS patients presenting with neurological events.