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Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats
S R Thaller1, M A Salzhauer, A J Rubinstein
1Department of Surgery, University of Miami, FL 33101, USA.
The Journal of Craniofacial Surgery
|May 20, 1998
Abstract:
Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley rats.