Influence of estrogens on intraocular tension in the eyeballs of rabbits

Iridocorneal angles from the eyes of female rabbits subjected to large doses of estrogens were examined under an electron scanning microscope. A temporary rise in intraocular tension was noted lasting up to 24 h after injection of estrogens, followed by a slow return to normal conditions. Histostructural changes of the iridicorneal angle were observed as widening of the marginal sector, enlarging of the dimple-shaped depressions and also increased number and narrowing of the micropores in the central part of the iridocorneal field. The authors postulate that estrogens affect the histostructure of the iridocorneal field and also stimulate the circulation of the aqueous fluid.