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The effect of intestinal permeability on pancreatic enzyme-induced enteropathy in the rat

J D Lloyd-Still1, M R Uhing, V Arango

  • 1Department of Pediatrics, Rush Medical College, Chicago, Illinois, USA.

Journal of Pediatric Gastroenterology and Nutrition
|May 20, 1998
PubMed

Insights

Excessive pancreatic enzymes combined with agents increasing intestinal permeability cause severe intestinal damage in a rat model. This finding is relevant to fibrosing colonopathy in cystic fibrosis patients.

Area of Science:

  • Gastroenterology
  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Fibrosing colonopathy affects children with cystic fibrosis (CF) aged 2-7 years.
  • It is linked to excessive doses of pancreatic lipase enzymes over 6 months.
  • A rat model was created to investigate these effects.

Purpose of the Study:

  • To examine the impact of excessive pancreatic enzyme doses on intestinal health.
  • To investigate the role of increased intestinal permeability in enzyme-induced damage.

Main Methods:

  • Five rat groups received varying combinations of pancreatic enzymes, oleic acid, and reserpine.
  • The study assessed the effects of these agents on the gastrointestinal tract and liver.

Main Results:

  • Pancreatic enzymes alone caused minimal intestinal damage and no liver damage.
  • Excessive enzymes with agents increasing intestinal permeability led to eosinophilia, jejunoileal muscle necrosis, and liver nodules.
  • Damage severity correlated with the duration of the insult.

Conclusions:

  • Increased intestinal permeability exacerbates intestinal damage from excessive pancreatic enzymes.
  • This mechanism may contribute to fibrosing colonopathy vulnerability in cystic fibrosis.
Abstract

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