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Updated: Aug 9, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
The multi-step nature of carcinogenesis and the implications for risk analysis
1National Radiological Protection Board, Chilton, Didcot, Oxon, UK.
Purpose:
For the purposes of constructing biologically realistic models of radiation cancer risk it is necessary to have detailed knowledge of the post-irradiation mechanisms involved.
Methods:
This brief review considers selected aspects of DNA damage response, tumour initiation/development, together with attendant factors and provides comment on the implications for cancer risk estimation and some of the uncertainties that remain.
Conclusions:
It is judged from studies with animal models that, in the main, radiation tumorigenesis proceeds in a conventional multi-step fashion following radiation-induced specific gene losses from single-target stem cells.
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