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Clinical conditions altering copper metabolism in humans
1Section of Pediatric Nutrition and Center for Human Nutrition, University of Colorado School of Medicine, Denver, USA.
The American Journal of Clinical Nutrition
|May 20, 1998
Summary
Copper deficiency is rare, but certain health conditions increase risk. Some illnesses and factors can also lead to copper excess, impacting public health.
Area of Science:
- Biochemistry
- Human Physiology
- Nutritional Science
Background:
- Copper is an essential trace element vital for numerous physiological processes.
- Overt copper deficiency is uncommon in the general population.
- Specific clinical scenarios can alter copper homeostasis, leading to deficiency or toxicity.
Purpose of the Study:
- To review clinical conditions associated with copper deficiency.
- To examine circumstances linked to elevated copper levels.
- To highlight the importance of monitoring copper status in at-risk individuals.
Main Methods:
- Literature review of case studies and documented conditions.
- Analysis of factors contributing to inadequate copper intake.
- Examination of conditions associated with excessive copper loss or increased concentration.
Main Results:
- Acquired copper deficiency is linked to poor intake, prematurity, malabsorption, and excessive losses.
- Increased copper concentrations are observed in stress, inflammation, infection, Parkinson disease, diabetes, and cholestasis.
- These findings underscore the variability of copper status in disease states.
Conclusions:
- While not a widespread public health issue, copper deficiency and excess pose risks in specific populations.
- Clinical awareness and monitoring are crucial for managing copper-related health conditions.
- Further research into the mechanisms of copper dysregulation in disease is warranted.