Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Copper and immunity

S S Percival1

  • 1Food Science and Human Nutrition Department, University of Florida, Gainesville 32611, USA. ssp@gnv.ifas.ufl.edu

The American Journal of Clinical Nutrition
|May 20, 1998
PubMed
Summary
This summary is machine-generated.

Copper is essential for immune function, impacting T cell proliferation and neutrophil activity. Even marginal copper deficiency can impair these crucial immune responses, highlighting the need for careful nutritional assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of residual and reapplied biosolids on performance and mineral status of grazing beef steers.

Journal of animal science·2002
Same author

Endothelial cell calcium mobilization to acetylcholine is attenuated in copper-deficient rats.

Endothelium : journal of endothelial cell research·2000
Same author

Effects of pasture applied biosolids on performance and mineral status of grazing beef heifers.

Journal of animal science·2000
Same author

Use of echinacea in medicine.

Biochemical pharmacology·2000
Same author

Wine modifies the effects of alcohol on immune cells of mice.

The Journal of nutrition·2000
Same author

Evaluating copper lysine and copper sulfate sources for heifers.

Journal of dairy science·2000
Same journal

Effect of fortified Bovine colostrum on linear growth of children aged 9-36 months: a community-based three-arm randomized controlled trial in urban slums of Belagavi city, India.

The American journal of clinical nutrition·2026
Same journal

Nourishing Collaboration: Interdisciplinary Nutrition Education for Health Care Professionals.

The American journal of clinical nutrition·2026
Same journal

Associations of red blood cell fatty acids with personality traits: 10-year follow-up in the Kibbutzim Family Study.

The American journal of clinical nutrition·2026
Same journal

Corrigendum to: Vitamin D status and breast cancer in Saudi Arabian women: case-control study [Am J Clin Nutr 98 (2013) 105-110].

The American journal of clinical nutrition·2026
Same journal

High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

The American journal of clinical nutrition·2026
Same journal

Reply to Wu et al.: "Nitrate and nitrite food composition database: an update and extensive deep dive".

The American journal of clinical nutrition·2026
See all related articles

Area of Science:

  • Immunology
  • Nutritional Science
  • Cell Biology

Background:

  • Copper is vital for immune system functions, though its precise mechanisms are not fully understood.
  • Previous research indicates copper deficiency affects interleukin 2 (IL-2) production and T cell proliferation.

Purpose of the Study:

  • To investigate the role of copper in immune cell function, particularly T cells and neutrophils.
  • To explore copper's impact on immune responses even in cases of marginal deficiency.

Main Methods:

  • Utilized animal models and cell culture studies, including HL-60 cells, to assess copper's effects.
  • Measured interleukin concentrations, T cell proliferation, neutrophil counts, and superoxide anion generation.

Main Results:

Related Experiment Videos

  • Copper deficiency reduces interleukin 2 and impairs T cell proliferation.
  • Marginal copper deficiency also negatively impacts immune responses.
  • Neutrophil numbers and their ability to kill microorganisms are reduced in both overt and marginal copper deficiency.

Conclusions:

  • Copper plays a critical role in maintaining T cell and neutrophil function.
  • Assessing copper-binding proteins in neutrophils may offer insights into copper's functions and status assessment.
  • Neutrophils show promise as a tool for evaluating nutrient status in human populations.