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Updated: Sep 21, 2026

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
Published on: May 27, 2016
[Physiopathology of human superficial radiation-induced fibrosis]
J L Lefaix1, S Delanian, B Dubray
1Laboratoire de Radiobiologie et d'Etude du Génome, DSV-DRR, CEA-Saclay, Gif-sur-Yvette.
Abstract:
The radiation-induced fibrosis is a late sequela of both therapeutic and accidental irradiations, and has been described in several tissues such as skin and underlying sub-cutaneous tissues, and lung. Based on the newest findings arising from cellular and molecular radiobiology, this review synthesis different aspects of the human superficial radiation-induced fibrosis: clinical and paraclinical observations, radiobiological aspects, gross histological changes, cellular and molecular regulations, and medical management. However, the underlying mechanisms of the superficial radiation-induced fibrosis still remain to be resolved.
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