Endocrine therapy of prostate cancer

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Updated: Oct 29, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

R L Bare1, F M Torti

  • 1Department of Urology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1094, USA.

Cancer Treatment and Research
|May 20, 1998
PubMed

Insights

Endocrine therapy helps manage metastatic prostate cancer symptoms and slow disease progression. However, it does not cure the cancer, highlighting the need for new nonendocrine treatments.

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Endocrine therapy is a standard treatment for metastatic prostate cancer.
  • Androgen deprivation therapy (ADT) is commonly used, providing symptomatic relief and delaying disease progression for many patients.

Purpose of the Study:

  • To evaluate the efficacy of endocrine therapy in metastatic prostate cancer.
  • To identify limitations of current endocrine therapies and the need for novel treatment strategies.

Main Methods:

  • This study reviews existing data on endocrine therapy for metastatic prostate cancer.
  • Analysis focuses on patient outcomes, including symptomatic relief and disease progression.

Main Results:

  • Endocrine therapy demonstrates significant effectiveness in managing symptoms and slowing the progression of metastatic prostate cancer.
  • A substantial number of patients experience benefits from androgen withdrawal.

Conclusions:

  • While effective for management, endocrine therapy does not offer a cure for metastatic prostate cancer.
  • The findings underscore the critical need for developing and investigating innovative nonendocrine therapies to achieve a cure.

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